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Search Results for " dual antagonist "

20

Compounds

Cat No. Product Name Synonyms Targets
T4584 BMS-813160 BMS 813160 CCR
BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
T36716 RO0270608 RO0270608
RO0270608, the active metabolite of R411, is a dual α4β1/α4β7 integrin antagonist with anti-inflammatory activity[1][2].
T61807 5-HT6/7 antagonist 1 Dopamine Receptor , 5-HT Receptor
5-HT6/7 antagonist 1 is a dual 5-HT6/7/2A and D2 receptor antagonist for the study of dementia and Alzheimer's disease.
TQ0029 ASTX660 IAP
ASTX660 is an orally bioavailable dual antagonist of cIAP and XIAP.
T62420 P2Y2R/GPR17 antagonist 1 GPR
P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R (IC50: 3.17 μM) and GPR17 (IC50: 1.67 μM) antagonist.
T2710 TCS 1102 OX Receptor
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
T10914 Cyclodrine hydrochloride AChR
Cyclodrine hydrochloride is a dual cholinergic muscarinic receptor (mAChR) and nicotinic receptor (nAChR) antagonist that can be used in the study of neurologically related diseases.
T67782 Daridorexant hydrochloride Nemorexant hydrochloride,Quviviq OX Receptor
Daridorexant hydrochloride (Nemorexant hydrochloride) is a New Dual Orexin Receptor Antagonist. Daridorexant hydrochloride can be used for Insomnia research.
T38144 Elinzanetant Neurokinin receptor
Elinzanetant is a dual antagonist of neurokinin (NK) receptors 1 and 3 and modulates reproductive hormone secretion.
T5500 DORA-22 OX Receptor
DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory
T14078 AB928 Adenosine Receptor
AB928 is an orally bioavailable, selective dual adenosine receptor (A2aR/A2bR) antagonist. It has immunomodulatory activity[1].
T24827 SR 16832 SR-16832,SR16832 PPAR
SR 16832 is a dual-site PPARγ inhibitor. It also inhibits the binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonist GW 9662 and T 0070907.
T6242 Rupatadine Fumarate Rinialer,Rupafin,Alergoliber PAFR , Autophagy , Histamine Receptor
Rupatadine Fumarate (Rinialer) (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM.
T5310 TR-14035 MDK-1191 Integrin
TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).
T16854 SB-674042 SB674042 OX Receptor
SB-674042 is a potent and selective dual antagonist of the non-peptide orexigenic peptides OX1 and OX2 receptors, with IC50s of 3.76 nM and 531 nM, respectively.SB-674042 can be used for the treatment of depression.
T17232 Vidupiprant AMG 853 Prostaglandin Receptor
Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma.
T12596 (4E)-SUN9221 5-HT Receptor , Adrenergic Receptor
(4E)-SUN9221 is a potent dual α1-adrenergic receptor and 5-HT2 receptor antagonist that shows antihypertensive and antiplatelet aggregation activity in hypertensive rats.
TQ0297 Cenicriviroc TAK-652,TBR-652 HIV Protease , CCR
Cenicriviroc (TAK-652) is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory activity.
T5355 Sparsentan RE-021,DARA-a RAAS , Endothelin Receptor
Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively)
T6265 Bosentan (hydrate) Bosentan Hydrate,Benzenesulfonamide,Actelion,Ro 47-0203 Endothelin Receptor
Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.
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TargetMol